Sulfuric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol

HRID 26928

반응식

HRID 26928 반응식
[OH:1][CH2:2][CH2:3][C:4](=[O:6])[CH3:5].Br[C:8]1[CH:13]=[CH:12][C:11]([C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=2[F:21])=[CH:10][CH:9]=1.[Mg].S(=O)(=O)(O)O>CCOCC>[F:21][C:15]1[CH:16]=[C:17]([F:20])[CH:18]=[CH:19][C:14]=1[C:11]1[CH:12]=[CH:13][C:8]([C:4]([OH:6])([CH3:5])[CH2:3][CH2:2][OH:1])=[CH:9][CH:10]=1

참가 물질

6

반응물 4

HCID 1118Sulfuric AcidHCID 1115094-Hydroxy-2-ButanoneHCID 5462224MagnesiumHCID 213226111,1'-Biphenyl, 4'-bromo-2,4-difluoro-

생성물 1

HCID 213225623-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol

시약·촉매·용매 1

HCID 3283Diethyl Ether용매3회

실험 절차

0.44 g. of 1 -hydroxy-3-butanone in 40 ml. of ether is added dropwise, at 20° to stirred Grignard solution obtained from 2.69 g. of 4-bromo-2',4'-difluorobiphenyl and 0.24 g. of magnesium in 100 ml. of ether. The mixture is stirred for two hours more and the resulting alcoholate is decomposed with dilute sulfuric acid. The ether phase is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.

후처리

  1. customobtained from 2.69 g
  2. stirringThe mixture is stirred for two hours more

출처 및 근거

ORD 기록
ord-d3e09d4998144f26af463aa41940b803
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151302

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