Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 1-(2',4'-Difluoro(1,1'-biphenyl)-4-yl)ethan-1-one | HCID 104542 | — |
| 반응물 | Sodium borohydride | HCID 4311764 | — |
| 반응물 | HCID 178467894 | HCID 178467894 | — |
| 생성물 | 3-(2',4'-Difluoro-4-biphenylyl)butane-1,3-diol | HCID 21322562 | — |
반응 단계
A solution of 2.76 g. of 3 hydroxy-3-(2',4'-difluoro-4-biphenylyl)-butanol, obtained by reacting 4-acetyl-2',4'-difluorobiphenyl with 2,2-diethoxyethyl magnesium bromide and subsequently hydrolyzing the reaction product, in 12 ml. of ethanol is added dropwise to a solution of 0.6 g. of NaBH4 in 15 ml. of ethanol. The mixture is stirred for two hours at 20° and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butane-1,3-diol, m.p. 82°-84°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04151302 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-03755bd438034524aa14d6fc3b6c6871 |
| 출처 메모 | uspto-grants-1979_04 |