Aluminium lithium hydride → (1H-Pyrrolo[2,3-b]pyridin-5-yl)methanol

HRID 269488노트

반응식

HRID 269488 반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[CH:13]=[CH:12][NH:11][C:8]2=[N:9][CH:10]=1)=O.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C1COCC1>[NH:11]1[C:8]2=[N:9][CH:10]=[C:5]([CH2:3][OH:2])[CH:6]=[C:7]2[CH:13]=[CH:12]1

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 22832049methyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate

생성물 1

HCID 22832050(1H-Pyrrolo[2,3-b]pyridin-5-yl)methanol수율 98%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester (75 mg, 0.394 mmol) in THF at 0 C was added lithium aluminum hydride (45 mg, 1.18 mmol) and the reaction mixture was slowly allowed to warm to ambient temperature. The reaction was refluxed for 12 hr, allowed to cool and quenched with water. Extraction with ethyl acetate, washed with brine, dried (Na2SO4) to afford (1H-Pyrrolo[2,3-b]pyridin-5-yl)-methanol (57 mg, 98% yield).

후처리

  1. temperatureThe reaction was refluxed for 12 hr
  2. temperatureto cool
  3. customquenched with water
  4. extractionExtraction with ethyl acetate
  5. washwashed with brine
  6. dry with materialdried (Na2SO4)

출처 및 근거

ORD 기록
ord-970f12e663a64fd8a5d51b42c818c26c
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446199B2

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