Diethyl Ether → 4-Benzyloxybenzotrifluoride

HRID 269550노트

반응식

HRID 269550 반응식
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][CH:3]=1.[CH2:12](Br)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(=O)([O-])[O-].[K+].[K+].C(OCC)C>CC(C)=O.O>[CH2:12]([O:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:9])([F:10])[F:11])=[CH:4][CH:3]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

참가 물질

7

반응물 4

HCID 3283Diethyl EtherHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 678744-(Trifluoromethyl)phenol

생성물 1

HCID 27981684-Benzyloxybenzotrifluoride

시약·촉매·용매 2

HCID 180Acetone용매HCID 962Water용매

실험 절차

A solution of 4-hydroxybenzotrifluoride (8.55 g, 52.78 mmol) in acetone (200 ml) was treated with benzyl bromide (9.87 g, 6.86 ml, 58.05 mmol) and potassium carbonate (10.94 g, 79.16 mmol). The mixture was stirred and heated to reflux under nitrogen for 3 h. After cooling, diethyl ether (400 ml) and water (400 ml) were added and the aqueous phase re-extracted with diethyl ether (100 ml). The combined organic layers were washed with water, dried (MgSO4) and the solvent removed in vacuo to leave the title compound as a white solid. (12.71 g, 95%)

후처리

  1. temperatureheated
  2. temperatureto reflux under nitrogen for 3 h
  3. temperatureAfter cooling
  4. extractionthe aqueous phase re-extracted with diethyl ether (100 ml)
  5. washThe combined organic layers were washed with water
  6. dry with materialdried (MgSO4)
  7. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-81ae0fc634cb473dbd06177920facf11
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446222B2

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