Iodine → 1-(Benzyloxy)-2-iodo-4-(trifluoromethyl)benzene

HRID 269551노트

반응식

HRID 269551 반응식
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.F[B-](F)(F)F.F[B-](F)(F)F.ClC[N+]12CC[N+](F)(CC1)CC2.[I:40]I>C(#N)C>[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:11][C:10]=1[I:40])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

5

반응물 3

HCID 807IodineHCID 2724933SelectfluorHCID 27981684-Benzyloxybenzotrifluoride

생성물 1

HCID 211129271-(Benzyloxy)-2-iodo-4-(trifluoromethyl)benzene수율 158.2%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 4(benzyloxy)benzotrifluoride (12.71 g, 50.4 mmol) in acetonitrile (300 ml) was stirred under nitrogen and 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (17.75 g, 50.4 mmol) and iodine (6.4 g, 25.2 mmol) added. The mixture was stirred at room temperature for 88 h. The solvent was evaporated and the residue partitioned between ethyl acetate (400 ml) and water (400 ml). The organic layer was washed with water, dried (MgSO4) and evaporated to an orange oil which was purified by flash chromatography (silica gel, 5% ethyl acetate:isohexane) to give the title compound as an orange oil (15.07 g, 79%)

후처리

  1. customThe solvent was evaporated
  2. customthe residue partitioned between ethyl acetate (400 ml) and water (400 ml)
  3. washThe organic layer was washed with water
  4. dry with materialdried (MgSO4)
  5. customevaporated to an orange oil which
  6. customwas purified by flash chromatography (silica gel, 5% ethyl acetate:isohexane)

출처 및 근거

ORD 기록
ord-036952fdfd3e46c183faa23186a493cf
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446222B2

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