Ethanol → 2-Bromo-5-chlorobenzoic acid ethyl ester

HRID 269554노트

반응식

HRID 269554 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[CH2:12](O)[CH3:13]>S(=O)(=O)(O)O>[Br:1][C:2]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][C:3]=1[C:4]([O:6][CH2:12][CH3:13])=[O:5]

참가 물질

4

반응물 2

HCID 702EthanolHCID 890272-Bromo-5-chlorobenzoic acid

생성물 1

HCID 693095662-Bromo-5-chlorobenzoic acid ethyl ester

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

A solution of 2-bromo-5-chlorobenzoic acid in ethanol (10 ml) and sulphuric acid (0.5 ml) was refluxed for 20 hours then cooled and evaporated. The residue was dissolved in diethyl ether/water and the organic layer dried (magnesium sulphate) and evaporated to give 516 mg of light brown oil.

후처리

  1. temperaturethen cooled
  2. customevaporated
  3. dissolutionThe residue was dissolved in diethyl ether/water
  4. dry with materialthe organic layer dried (magnesium sulphate)
  5. customevaporated

출처 및 근거

ORD 기록
ord-53864e97ac024a7b8db7f1a8a5c79c24
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446222B2

반응 노트

불러오는 중…