Benzyl Bromide → 2-(Benzyloxy)-3-bromo-5-chloropyridine

HRID 269581노트

반응식

HRID 269581 반응식
[Br:1][C:2]1[C:3]([OH:9])=[N:4][CH:5]=[C:6]([Cl:8])[CH:7]=1.[CH2:10](Br)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C1(C)C=CC=CC=1.C(=O)([O-])[O-].[Ag+2]>[CH2:10]([O:9][C:3]1[C:2]([Br:1])=[CH:7][C:6]([Cl:8])=[CH:5][N:4]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

5

반응물 2

HCID 7498Benzyl BromideHCID 178517755HCID 178517755, 화합물

생성물 1

HCID 220583822-(Benzyloxy)-3-bromo-5-chloropyridine

시약·촉매·용매 2

HCID 178418647HCID 178418647, 화합물촉매HCID 1140Toluene용매

실험 절차

3-Bromo-5-chloro-2-pyridinol (7.0 g, 33.6 mmol) was stirred in toluene (160 ml) and silver carbonate (10.23 g, 36.9 mmol) added, followed by benzyl bromide (6.32 g, 4.39 ml, 36.9 mmol). The mixture was heated to reflux for 1 hour. After cooling, the mixture was filtered, washed with water (×2), dried (MgSO4) and evaporated. The residue was triturated with isohexane and the pale yellow solid filtered and dried. (8.36 g).

후처리

  1. temperatureThe mixture was heated
  2. temperatureto reflux for 1 hour
  3. temperatureAfter cooling
  4. filtrationthe mixture was filtered
  5. washwashed with water (×2)
  6. dry with materialdried (MgSO4)
  7. customevaporated
  8. customThe residue was triturated with isohexane
  9. filtrationthe pale yellow solid filtered
  10. customdried

출처 및 근거

ORD 기록
ord-d4369e9f678b4d7381f563c85bf92a92
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446222B2

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