Potassium sodium tartarate → (2-(Benzyloxy)-5-iodophenyl)methanol

HRID 269594노트

반응식

HRID 269594 반응식
[H-].C([Al+]CC(C)C)C(C)C.[CH2:11]([O:18][C:19]1[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:20]=1[CH:21]=[O:22])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(C(C(C([O-])=O)O)O)([O-])=O.[Na+].[K+]>ClCCl>[CH2:11]([O:18][C:19]1[CH:26]=[CH:25][C:24]([I:27])=[CH:23][C:20]=1[CH2:21][OH:22])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

5

반응물 3

HCID 9855836Potassium sodium tartarateHCID 150434892-(Benzyloxy)-5-iodobenzaldehydeHCID 21225700Diisobutylaluminumhydride

생성물 1

HCID 59831381(2-(Benzyloxy)-5-iodophenyl)methanol

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

반응 조건

온도
0 °C

실험 절차

100 ml of a 1M diisobutylaluminum hydride solution in dichloromethane are added to a solution, cooled to 0° C., of 33.98 g (100.5 mmol) of 2-benzyloxy-5-iodobenzaldehyde (Example 2A) in 200 ml of dichloromethane. After stirring at 0° C. for 2 h, a saturated potassium sodium tartrate solution is added while cooling (highly exothermic reaction), and the reaction mixture is stirred for a further 2 h. After the separation of the phases, the organic phase is washed twice with water and once with a saturated aqueous sodium chloride solution and dried over sodium sulfate. The solvent is evaporated in vacuo. 31.8 g (93% of theory) of product are obtained.

후처리

  1. temperaturewhile cooling (
  2. customhighly exothermic reaction), and the reaction mixture
  3. stirringis stirred for a further 2 h
  4. customAfter the separation of the phases
  5. washthe organic phase is washed twice with water and once with a saturated aqueous sodium chloride solution
  6. dry with materialdried over sodium sulfate
  7. customThe solvent is evaporated in vacuo
  8. custom31.8 g (93% of theory) of product are obtained

출처 및 근거

ORD 기록
ord-7bcd6824560e4b9c9644522f7863956a
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

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