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benzyl(2-{[(3S)-3-{[(benzyloxy)carbonyl]amino}-6-({[(8S,11S,14S)-14-[(tert-butoxycarbonyl)amino]-11-{3-[(tert-butoxycarbonyl)amino]propyl}-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-8-yl]carbonyl}amino)hexanoyl]amino}ethyl)carbamate → HCID 70806691, 화합물

HRID 269661
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HRID 269661 반응식
C(OC(=O)[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:78])[CH2:15][C@@H:16]([NH:67]C(OCC1C=CC=CC=1)=O)[CH2:17][CH2:18][CH2:19][NH:20][C:21]([C@H:23]1[NH:41][C:40](=[O:42])[C@H:39]([CH2:43][CH2:44][CH2:45][NH:46][C:47]([O:49][C:50]([CH3:53])([CH3:52])[CH3:51])=[O:48])[NH:38][C:37](=[O:54])[C@@H:36]([NH:55][C:56]([O:58][C:59]([CH3:62])([CH3:61])[CH3:60])=[O:57])[CH2:35][C:34]2[CH:63]=[C:30]([CH:31]=[CH:32][C:33]=2[OH:64])[C:29]2=[CH:65][C:25](=[C:26]([OH:66])[CH:27]=[CH:28]2)[CH2:24]1)=[O:22])C1C=CC=CC=1>[Pd].C(O)(=O)C.O.C(O)C>[C:50]([O:49][C:47](=[O:48])[NH:46][CH2:45][CH2:44][CH2:43][C@@H:39]1[NH:38][C:37](=[O:54])[C@@H:36]([NH:55][C:56]([O:58][C:59]([CH3:62])([CH3:61])[CH3:60])=[O:57])[CH2:35][C:34]2[CH:63]=[C:30]([CH:31]=[CH:32][C:33]=2[OH:64])[C:29]2=[CH:65][C:25](=[C:26]([OH:66])[CH:27]=[CH:28]2)[CH2:24][C@@H:23]([C:21]([NH:20][CH2:19][CH2:18][CH2:17][C@H:16]([NH2:67])[CH2:15][C:14]([NH:13][CH2:12][CH2:11][NH2:10])=[O:78])=[O:22])[NH:41][C:40]1=[O:42])([CH3:51])([CH3:52])[CH3:53]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 131727165benzyl(2-{[(3S)-3-{[(benzyloxy)carbonyl]amino}-6-({[(8S,11S,14S)-14-[(tert-butoxycarbonyl)amino]-11-{3-[(tert-butoxycarbonyl)amino]propyl}-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-8-yl]carbonyl}amino)hexanoyl]amino}ethyl)carbamate

생성물 1

HCID 70806691HCID 70806691, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매
HCID 86584229
Acetic acid ethanol water
용매

실험 절차

12 mg (0.011 mmol) of benzyl(2-{[(3S)-3-{[(benzyloxy)carbonyl]amino}-6-({[(8S,11S,14S)-14-[(tert-butoxycarbonyl)amino]-11-{3-[(tert-butoxycarbonyl)amino]propyl}-5,17-dihydroxy-10,13-dioxo-9,12-diazatricyclo[14.3.1.12,6]henicosa-1(20),2(21),3,5,16,18-hexaen-8-yl]carbonyl}amino)hexanoyl]amino}ethyl)carbamate (Example 190A) are added into 3 ml of a 4:1:1 acetic acid/water/ethanol mixture. 1.5 mg of palladium on activated carbon (10%) are added thereto, and the mixture is then hydrogenated at RT under atmospheric pressure for 15 h. The reaction mixture is filtered through prewashed kieselguhr and washed with ethanol, and the filtrate is concentrated on a rotary evaporator in vacuo.

후처리

  1. filtrationThe reaction mixture is filtered through prewashed kieselguhr
  2. washwashed with ethanol
  3. concentrationthe filtrate is concentrated on a rotary evaporator in vacuo

출처 및 근거

ORD 기록
ord-7a3ab6b1c65a493bb4e75959289da004
출처 데이터셋
uspto-grants-2008_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07446102B2

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