Benzyl[3-({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)-3-oxopropyl]carbamate → tert-Butyl {(4S)-5-[(3-aminopropanoyl)amino]-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate

HRID 269675노트

반응식

HRID 269675 반응식
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]([NH:15][CH2:16][C@@H:17]([NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:18][CH2:19][CH2:20][NH:21][C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])=[O:14])C1C=CC=CC=1>[Pd].C(O)C>[C:25]([O:24][C:22](=[O:23])[NH:21][CH2:20][CH2:19][CH2:18][C@H:17]([NH:29][C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:16][NH:15][C:13](=[O:14])[CH2:12][CH2:11][NH2:10])([CH3:27])([CH3:28])[CH3:26]

참가 물질

4

반응물 1

HCID 131727169Benzyl[3-({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)-3-oxopropyl]carbamate

생성물 1

HCID 86625291tert-Butyl {(4S)-5-[(3-aminopropanoyl)amino]-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

40 mg of palladium on activated carbon (10%) are added to a mixture of 0.215 g (0.41 mmol) of the compound from Example 242A in 10 ml of ethanol, and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.

후처리

  1. filtrationThe reaction mixture is filtered through kieselguhr
  2. concentrationthe filtrate is concentrated in vacuo
  3. customdried under high vacuum
  4. customThe crude product is reacted without further purification

출처 및 근거

ORD 기록
ord-1e3b562907fd4facb4e26f4934f28859
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

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