Benzyl[3-({2-[(tert-butoxycarbonyl)amino]ethyl}amino)-3-oxopropyl]carbamate → HCID 86619445, 화합물
반응식
C(OC(=O)[NH:10][CH2:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])C1C=CC=CC=1>[Pd].C(O)C>[C:22]([O:21][C:19]([NH:18][CH2:17][CH2:16][NH:15][C:13](=[O:14])[CH2:12][CH2:11][NH2:10])=[O:20])([CH3:25])([CH3:23])[CH3:24]참가 물질
4
실험 절차
80 mg of palladium on activated carbon (10%) are added to a mixture of 0.30 g (0.82 mmol) of the compound from Example 254A in 10 ml of ethanol, and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.
후처리
- filtrationThe reaction mixture is filtered through kieselguhr
- concentrationthe filtrate is concentrated in vacuo
- customdried under high vacuum
- customThe crude product is reacted without further purification
출처 및 근거
- ORD 기록
- ord-4cdc0a2603814763878ae61d8cd8cc04
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07446102B2
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