HCID 86624523, 화합물 → HCID 86624524, 화합물

HRID 269690노트

반응식

HRID 269690 반응식
C(OC(=O)[NH:10][CH2:11][C@H:12]([NH:26][C:27]([O:29][C:30]([CH3:33])([CH3:32])[CH3:31])=[O:28])[C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])C1C=CC=CC=1>[Pd].C(O)(=O)C.C(O)C.O>[NH2:10][CH2:11][C@@H:12]([C:13]([NH:15][CH2:16][CH2:17][NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])=[O:14])[NH:26][C:27]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:28]

참가 물질

4

반응물 1

HCID 86624523HCID 86624523, 화합물

생성물 1

HCID 86624524HCID 86624524, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 86584229Acetic acid ethanol water용매

실험 절차

50 mg of palladium on activated carbon (10%) are added to a mixture of 0.41 g (0.847 mmol) of the compound from Example 260A in 80 ml of acetic acid/ethanol/water (4:1:1), and the mixture is then hydrogenated under atmospheric pressure for 12 h. The reaction mixture is filtered through kieselguhr, and the filtrate is concentrated in vacuo and dried under high vacuum. The crude product is reacted without further purification.

후처리

  1. filtrationThe reaction mixture is filtered through kieselguhr
  2. concentrationthe filtrate is concentrated in vacuo
  3. customdried under high vacuum
  4. customThe crude product is reacted without further purification

출처 및 근거

ORD 기록
ord-c527f1d8356c45059f3c1a3f0bfc498b
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446102B2

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