Phenethylamine → N-[[2-[3-(1-Piperidinyl)propoxy]phenyl]methylene]benzeneethanamine

HRID 26971노트

반응식

HRID 26971 반응식
[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=2[CH:13]=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:19]([NH2:27])[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>C1(C)C=CC=CC=1>[N:1]1([CH2:7][CH2:8][CH2:9][O:10][C:11]2[CH:18]=[CH:17][CH:16]=[CH:15][C:12]=2[CH:13]=[N:27][CH2:19][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 1001PhenethylamineHCID 137952592-[3-(1-Piperidinyl)propoxy]benzaldehyde

생성물 1

HCID 21322776N-[[2-[3-(1-Piperidinyl)propoxy]phenyl]methylene]benzeneethanamine수율 91.8%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

2-[3-(1-Piperidinyl)propoxy]benzaldehyde (47.6 g) is reacted with 24 g of phenethylamine in 190 ml of toluene following the procedure described in Example 1A to yield 61.9 g of product as an oil, boiling point 214°-218° C. at 0.2-0.3 mm of Hg.

출처 및 근거

ORD 기록
ord-77589dc074c64d02b6d2d37be4ed4702
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04151354

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