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Pyridinium chloride → 4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)thio]phenyl)amino)-7-fluoroquinoline-3-carbonitrile

HRID 269758
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HRID 269758 반응식
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[C:13]#[N:14].[Cl:15][C:16]1[CH:17]=[C:18]([NH2:29])[CH:19]=[CH:20][C:21]=1[S:22][C:23]1[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=1.Cl.N1C=CC=CC=1>C(OCCO)C>[Cl:15][C:16]1[CH:17]=[C:18]([NH:29][C:2]2[C:11]3[C:6](=[CH:7][C:8]([F:12])=[CH:9][CH:10]=3)[N:5]=[CH:4][C:3]=2[C:13]#[N:14])[CH:19]=[CH:20][C:21]=1[S:22][C:23]1[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=1
참가 물질실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 10176127Pyridinium chlorideHCID 114590883-chloro-4-(1-methyl-1H-imidazol-2-ylsulfanyl)phenylamineHCID 234980814-Chloro-7-fluoroquinoline-3-carbonitrile

생성물 1

HCID 684601654-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)thio]phenyl)amino)-7-fluoroquinoline-3-carbonitrile

시약·촉매·용매 1

HCID 8076Glycol monoethyl ether용매

실험 절차

Following the procedure of Example 1, a mixture of 1.2 g (5.81 mmol) 4-chloro-7-fluoro-3-quinolinecarbonitrile, 1.53 g (6.39 mmol) of 3-chloro-4-(1-methyl-1H-imidazole-2-ylsulfanyl)phenylamine and 0.671 g (5.81 mmol) of pyridine hydrochloride are refluxed in 2-ethoxyethanol (12 mL) at 120° C. for 45 minutes to yield 4-({3-chloro-4-[(1-methyl-1H-imidazole-2-yl)thio]phenyl}amino)-7-fluoroquinoline-3-carbonitrile as an off-white solid, mp 268-272° C.

출처 및 근거

ORD 기록
ord-808eec6e3d3141038c2d60a269b62030
출처 데이터셋
uspto-grants-2008_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07449460B2

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