참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Chloro-2-methylthiopyrimidine | HCID 97113 | — |
| 반응물 | Potassium Fluoride | HCID 522689 | — |
| 촉매 | 18-Crown-6 | HCID 28557 | — |
| 용매 | Tetraglyme | HCID 8925 | — |
| 생성물 | 4-Fluoro-2-(methylsulfanyl)pyrimidine | HCID 10261244 | 63.1% |
반응 단계
To a solution of 35.7 g (0.22 mol) of 4-chloro-2-methylthiopyrimidine (Aldrich Chemical Co., Milwaukee, Wis., USA) in 135 mL of tetraglyme was added 18-crown-6 (1.33 g) and potassium fluoride (Anhydrous, Aldrich Chemical Co., Milwaukee, Wis., USA, 80 g). The mixture was heated at 150° C. with stirring for 16 hours. The mixture was then cooled and distilled under reduced pressure to give 20 g (62%) of 4-fluoro-2-methylthiopyrimidine as a liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07449472B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_11 |
|---|
| ORD ID | ord-83fea8c78744466195b1cf09f776ec01 |
|---|
| 출처 메모 | uspto-grants-2008_11 |
|---|
