1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazine → 2-[4-(3-Cyclohexylpropyl)piperazin-1-yl]-5-hydroxybenzonitrile

HRID 269878노트

반응식

HRID 269878 반응식
COC1C=CC(N2CCN(CCC3C=CC=CC=3)CC2)=CC=1C.[CH:24]1([CH2:30][CH2:31][CH2:32][N:33]2[CH2:38][CH2:37][N:36]([C:39]3[CH:46]=[CH:45][C:44]([O:47]C)=[CH:43][C:40]=3[C:41]#[N:42])[CH2:35][CH2:34]2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1>>[CH:24]1([CH2:30][CH2:31][CH2:32][N:33]2[CH2:38][CH2:37][N:36]([C:39]3[CH:46]=[CH:45][C:44]([OH:47])=[CH:43][C:40]=3[C:41]#[N:42])[CH2:35][CH2:34]2)[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]1

참가 물질

3

반응물 2

HCID 231115101-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazineHCID 231115132-[4-(3-Cyclohexylpropyl)piperazin-1-yl]-5-methoxybenzonitrile

생성물 1

HCID 231114472-[4-(3-Cyclohexylpropyl)piperazin-1-yl]-5-hydroxybenzonitrile수율 62.1%

실험 절차

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 2-[4-(3-cyclohexylpropyl)piperazin-1-yl]-5-methoxybenzonitrile (430 mg), and the resulting crude product was purified on TLC (developer, chloroform: methanol=10:1) to provide 2-[4-(3-cyclohexylpropyl)piperazin-1-yl]-5-hydroxybenzonitrile (256 mg).

후처리

  1. customthe resulting crude product was purified on TLC (developer, chloroform: methanol=10:1)

출처 및 근거

ORD 기록
ord-fd8057679ebb47129fadc986d61d573f
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449466B2

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