1-Phenethylpiperazine → 1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine

HRID 269881

반응식

HRID 269881 반응식
BrC1C=CC(OC)=C(C)C=1.[CH2:11]([O:18][C:19]1[CH:24]=[CH:23][C:22](Br)=[CH:21][C:20]=1[Cl:26])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(N1CCNCC1)CC1C=CC=CC=1.[CH:41]1([CH2:47][CH2:48][CH2:49][N:50]2[CH2:55][CH2:54][NH:53][CH2:52][CH2:51]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH2:11]([O:18][C:19]1[CH:24]=[CH:23][C:22]([N:53]2[CH2:54][CH2:55][N:50]([CH2:49][CH2:48][CH2:47][CH:41]3[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]3)[CH2:51][CH2:52]2)=[CH:21][C:20]=1[Cl:26])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

참가 물질

5

반응물 4

HCID 792141-PhenethylpiperazineHCID 6083154-Bromo-1-methoxy-2-methylbenzeneHCID 27373931-(3-Cyclohexylpropyl)piperazineHCID 109135241-Benzyloxy-4-bromo-2-chlorobenzene

생성물 1

HCID 231114081-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine수율 100.4%

실험 절차

Production Example 9 was repeated except that 5-bromo-2-methoxytoluene was replaced with 1-benzyloxy-4-bromo-2-chlorobenzene (861 mg), and l-phenethylpiperazine was replaced with 1-(3-cyclohexylpropyl)piperazine (730 mg). Whereby obtained crude product was purified on silica gel column chromatography (eluent, chloroform: methanol=10:1) to provide 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine (1.24 g).

후처리

  1. customWhereby obtained crude product
  2. customwas purified on silica gel column chromatography (eluent, chloroform: methanol=10:1)

출처 및 근거

ORD 기록
ord-710a741b900940cbb5069251e283564b
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449466B2

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