1-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine → 3-Chloro-4-(4-phenethylpiperazin-1-yl)phenol

HRID 269888노트

반응식

HRID 269888 반응식
C(OC1C=CC(N2CCN(CCCC3CCCCC3)CC2)=CC=1Cl)C1C=CC=CC=1.C([O:38][C:39]1[CH:44]=[CH:43][C:42]([N:45]2[CH2:50][CH2:49][N:48]([CH2:51][CH2:52][C:53]3[CH:58]=[CH:57][CH:56]=[CH:55][CH:54]=3)[CH2:47][CH2:46]2)=[C:41]([Cl:59])[CH:40]=1)C1C=CC=CC=1>>[Cl:59][C:41]1[CH:40]=[C:39]([OH:38])[CH:44]=[CH:43][C:42]=1[N:45]1[CH2:50][CH2:49][N:48]([CH2:51][CH2:52][C:53]2[CH:54]=[CH:55][CH:56]=[CH:57][CH:58]=2)[CH2:47][CH2:46]1

참가 물질

3

반응물 2

HCID 231114081-(4-Benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazineHCID 231114621-(4-Benzyloxy-2-chlorophenyl)-4-phenethylpiperazine

생성물 1

HCID 231114233-Chloro-4-(4-phenethylpiperazin-1-yl)phenol수율 57.3%

실험 절차

Production Example 30 was repeated except that 1-(4-benzyloxy-3-chlorophenyl)-4-(3-cyclohexylpropyl)piperazine was replaced with 1-(4-benzyloxy-2-chlorophenyl)-4-phenethylpiperazine (65 mg). Thus obtained crude product was purified on TLC (developer, chloroform: methanol=17:1) to provide 3-chloro-4-(4-phenethylpiperazin-1-yl)phenol (29 mg).

후처리

  1. customThus obtained crude product
  2. customwas purified on TLC (developer, chloroform: methanol=17:1)

출처 및 근거

ORD 기록
ord-77d3e002ee714f3e8073cfe440fda64d
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449466B2

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