1-Phenethylpiperazine → 1-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine

HRID 269896

반응식

BrC1C=CC(OC)=C(C)C=1.C1(CCN2CCNCC2)C=CC=CC=1.[CH2:25]([O:32][C:33]1[CH:38]=[CH:37][C:36](Br)=[CH:35][C:34]=1[F:40])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[CH:41]1([CH2:47][CH2:48][CH2:49][N:50]2[CH2:55][CH2:54][NH:53][CH2:52][CH2:51]2)[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]1>>[CH2:25]([O:32][C:33]1[CH:38]=[CH:37][C:36]([N:53]2[CH2:54][CH2:55][N:50]([CH2:49][CH2:48][CH2:47][CH:41]3[CH2:46][CH2:45][CH2:44][CH2:43][CH2:42]3)[CH2:51][CH2:52]2)=[CH:35][C:34]=1[F:40])[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1

참가 물질

반응물 4

HCID 792141-Phenethylpiperazine

HCID 6083154-Bromo-1-methoxy-2-methylbenzene

HCID 27373931-(3-Cyclohexylpropyl)piperazine

HCID 187574911-(Benzyloxy)-4-bromo-2-fluorobenzene

생성물 1

HCID 231114151-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine수율 111.4%

실험 절차

Production Example 9 was repeated except that 5-bromo-2-methoxytoluene and 1-(2-phenylethyl)piperazine were replaced with 1-benzyloxy-4-bromo-2-fluorobenzene (1.42 g) and 1-(3-cyclo-hexylpropyl)piperazine (1.28 g), respectively, to provide crude 1-(4-benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine (2.31 g).

출처 및 근거

ORD 기록: ord-c63e18e059fe474497463d85a52780e9
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07449466B2

연결된 노트

불러오는 중…