Phenethyl bromide → 1-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine

HRID 269897

반응식

Cl.Cl.COC1C=CC(N2CCNCC2)=CC=1.BrCCC1C=CC=CC=1.[CH2:26]([O:33][C:34]1[CH:39]=[CH:38][C:37]([N:40]2[CH2:45][CH2:44][NH:43][CH2:42][CH2:41]2)=[CH:36][C:35]=1[F:46])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.CS(O[CH2:52][CH2:53][CH2:54][CH:55]1[CH2:60][CH2:59][CH2:58][CH2:57][CH2:56]1)(=O)=O>>[CH2:26]([O:33][C:34]1[CH:39]=[CH:38][C:37]([N:40]2[CH2:45][CH2:44][N:43]([CH2:52][CH2:53][CH2:54][CH:55]3[CH2:60][CH2:59][CH2:58][CH2:57][CH2:56]3)[CH2:42][CH2:41]2)=[CH:36][C:35]=1[F:46])[C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

참가 물질

반응물 4

HCID 7666Phenethyl bromide

HCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochloride

HCID 231114433-Cyclohexylpropyl methanesulfonate

HCID 231114831-(4-Benzyloxy-3-fluorophenyl)piperazine

생성물 1

HCID 231114151-(4-Benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine수율 99.4%

실험 절차

Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(4-benzyloxy-3-fluorophenyl)piperazine (1.33 g) and 3-cyclohexylpropyl methanesulfonate (1.02 g), respectively, to provide crude 1-(4-benzyloxy-3-fluorophenyl)-4-(3-cyclohexylpropyl)piperazine (1.89 g).

출처 및 근거

ORD 기록: ord-f01d874272804e85a16b83c59fcf2d1d
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07449466B2

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