Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methoxymethyl-triphenylphosphonium chloride → (Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methoxymethyl-triphenylphosphonium chloride | HCID 2723798 | — |
| 반응물 | Phenethyltriphenylphosphonium bromide | HCID 10863251 | — |
| 반응물 | 1-(2,5-Difluoro-4-methoxyphenyl)piperidin-4-one | HCID 23111466 | — |
| 반응물 | 1-(2,5-Difluoro-4-methoxyphenyl)-4-piperidinecarbaldehyde | HCID 23111501 | — |
| 생성물 | (Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine | HCID 67526767 | 78.6% |
반응 단계
Production Example 74 was repeated except that methoxymethyltriphenylphosphonium chloride and 1-(2,5-difluoro-4-methoxyphenyl)piperidin-4-one were replaced with phenethyltri-phenylphosphonium bromide (133 mg) and 1-(2,5-difluoro-4-methoxyphenyl)-4-piperidinecarbaldehyde (35 mg), respectively, and the resulting crude product was purified on TLC (developer, hexane: ethyl acetate=10:1) to provide (Z)-1-(2,5-difluoro-4-methoxyphenyl)-4-(3-phenyl-1-propen-1-yl)piperidine (37 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07449466B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-67f811637d1746b9803a3db98e54a5be |
| 출처 메모 | uspto-grants-2008_11 |