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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 269924생성일: 2026년 10월 27일

1-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine → 4-[4-(2-Cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol

https://huagongshe.com/reaction/269924

반응식

참여 물질

역할이름HCID투입량
반응물1-(2-Cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazineHCID 23111479—
반응물1-(4-Methoxy-3-methylphenyl)-4-phenethylpiperazineHCID 23111510—
생성물4-[4-(2-Cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenolHCID 2311146036.3%

반응 단계

Production Example 10 was repeated except that 1-(4-methoxy-3-methylphenyl)-4-phenethylpiperazine was replaced with 1-(2-cyclohexylethyl)-4-(2,5-difluoro-4-methoxyphenyl)-piperazine (250 mg). The resulting crude product was purified on TLC (developer, chloroform: methanol=13:1) to provide 4-[4-(2-cyclohexylethyl)piperazin-1-yl]-2,5-difluorophenol (87 mg).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07449466B2
출처 데이터셋uspto-grants-2008_11
ORD IDord-60e5a080e5344211a2f049a0081f27ba
출처 메모uspto-grants-2008_11