Phenethyl bromide → 1-(3-Cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine

HRID 269926

반응식

Cl.Cl.COC1C=CC(N2CCNCC2)=CC=1.Br[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.[F:26][C:27]1[CH:32]=[C:31]([O:33][CH3:34])[C:30]([F:35])=[CH:29][C:28]=1[N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1.CS(OCCCC1CCCC1)(=O)=O>>[CH:25]1([CH2:20][CH2:19][CH2:18][N:39]2[CH2:40][CH2:41][N:36]([C:28]3[CH:29]=[C:30]([F:35])[C:31]([O:33][CH3:34])=[CH:32][C:27]=3[F:26])[CH2:37][CH2:38]2)[CH2:24][CH2:23][CH2:22][CH2:21]1

참가 물질

반응물 4

HCID 7666Phenethyl bromide

HCID 27237001-(4-Methoxyphenyl)-piperazine, dihydrochloride

HCID 231114353-Cyclopentylpropyl methanesulfonate

HCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

생성물 1

HCID 231113951-(3-Cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine

실험 절차

Production Example 1 was repeated except that 1-(4-methoxyphenyl)piperazine dihydrochloride and (2-bromoethyl)-benzene were replaced with 1-(2,5-difluoro-4-methoxyphenyl)-piperazine (342 mg) and 3-cyclopentylpropyl methylsulfonate (309 mg), respectively, to provide crude 1-(3-cyclopentylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (486 mg).

출처 및 근거

ORD 기록: ord-4354032514ac42e6a155f6e50c6a0ce8
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07449466B2

연결된 노트

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