Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Bromooctane → 1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Bromooctane | HCID 8140 | — |
| 반응물 | (3-Chloropropyl)cyclohexane | HCID 70762 | — |
| 반응물 | 1-(4-Benzyloxy-3-fluorophenyl)piperazine | HCID 23111483 | — |
| 반응물 | 1-(2,5-Difluoro-4-methoxyphenyl)piperazine | HCID 23111492 | — |
| 생성물 | 1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine | HCID 23111426 | 97.1% |
반응 단계
Production Example 38 was repeated except that 1-(4-benzyloxy-3-fluorophenyl)piperazine and n-octyl bromide were replaced with 1-(2,5-difluoro-4-methoxyphenyl)piperazine (228 mg) and 3-cyclohexylpropyl chloride (161 mg). The resulting crude product was purified on silica gel column chromatography (eluent, ethyl acetate) to provide 1-(3-cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (342 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07449466B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-644ec63d6cc74fe2a71d0683d60d8240 |
| 출처 메모 | uspto-grants-2008_11 |