1-Bromooctane → 1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine

HRID 269929

반응식

C(OC1C=CC(N2CCNCC2)=CC=1F)C1C=CC=CC=1.C(Br)CCCCCCC.[F:31][C:32]1[CH:37]=[C:36]([O:38][CH3:39])[C:35]([F:40])=[CH:34][C:33]=1[N:41]1[CH2:46][CH2:45][NH:44][CH2:43][CH2:42]1.CS(O[CH2:52][CH2:53][CH2:54][CH:55]1[CH2:60][CH2:59][CH2:58][CH2:57][CH2:56]1)(=O)=O>>[CH:55]1([CH2:54][CH2:53][CH2:52][N:44]2[CH2:45][CH2:46][N:41]([C:33]3[CH:34]=[C:35]([F:40])[C:36]([O:38][CH3:39])=[CH:37][C:32]=3[F:31])[CH2:42][CH2:43]2)[CH2:60][CH2:59][CH2:58][CH2:57][CH2:56]1

참가 물질

반응물 4

HCID 81401-Bromooctane

HCID 231114433-Cyclohexylpropyl methanesulfonate

HCID 231114831-(4-Benzyloxy-3-fluorophenyl)piperazine

HCID 231114921-(2,5-Difluoro-4-methoxyphenyl)piperazine

생성물 1

HCID 231114261-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine수율 97.6%

실험 절차

Production Example 38 was repeated except that 1-(4-benzyloxy-3-fluorophenyl)piperazine and n-octyl bromide were replaced with 1-(2,5-difluoro-4-methoxyphenyl)piperazine (5.72 g) and 3-cyclohexylpropyl methanesulfonate (5.52 g), to provide crude 1-(3-cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine (8.618 g).

출처 및 근거

ORD 기록: ord-1b0415f35aed4884926bf0f098b46b1e
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07449466B2

연결된 노트

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