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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 269934생성일: 2026년 10월 26일

1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]butan-1-one → 1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-hydroxyphenyl)piperazin-1-yl]butan-1-one

https://huagongshe.com/reaction/269934

반응식

참여 물질

역할이름HCID투입량
반응물1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]butan-1-oneHCID 23111410—
반응물1-(3-Cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazineHCID 23111426—
생성물1-(4-Tert-butylphenyl)-4-[4-(2,5-difluoro-4-hydroxyphenyl)piperazin-1-yl]butan-1-oneHCID 2311145545.7%

반응 단계

Production Example 94 was repeated except that 1-(3-cyclohexylpropyl)-4-(2,5-difluoro-4-methoxyphenyl)piperazine was replaced with 1-(4-tert-butylphenyl)-4-[4-(2,5-difluoro-4-methoxyphenyl)piperazin-1-yl]butan-1-one (330 mg). The resulting crude product was purified on TLC (developer, ethyl acetate: hexane=2:1) to provide 1-(4-tert-butylphenyl)-4-[4-(2,5-difluoro-4-hydroxyphenyl)piperazin-1-yl]butan-1-one (146 mg).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07449466B2
출처 데이터셋uspto-grants-2008_11
ORD IDord-04100dbdd2e84cd0b5b8eed414d74221
출처 메모uspto-grants-2008_11