Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 270생성일: 2026년 10월 23일
3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline → (R)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepin-2-amine
https://huagongshe.com/ko/reaction/270
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline | HCID 45480181 | — |
| 반응물 | (R)-2-chloro-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine | HCID 59577867 | — |
| 시약 | Sodium 2-methylbutan-2-olate | HCID 2733478 | — |
| 촉매 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 촉매 | Palladium (II) acetate | HCID 4144353 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (R)-N-(3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl)-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepin-2-amine | HCID 49820859 | 0% |
반응 단계
(R)-2-chloro-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine (0.05 g, 0.18 mmol), PALLADIUM(II) ACETATE (1.221 mg, 5.44 µmol) (1.6), 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (0.037 g, 0.18 mmol) (0.64), Tri-tert- butylphosphonium tetrafluoriborate (0.0043 g, 0.014 mmol, 6 mol%) and Na-t-amilate (0.022 g, 1.1 equ, 0.2 mmol) in 1 ml of dioxane was degaset over argone and heated in MW 120°C 30 min. No reaction. Experiment was not progressed.
출처 및 근거
| 출처 데이터셋 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-3a2eb97137e148aba58c08979aa7d29e |
|---|
| 출처 메모 | 750 AstraZeneca ELN dataset |
|---|
