Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Benzyl-4-piperidone → 1'-Benzyl-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Benzyl-4-piperidone | HCID 19220 | — |
| 반응물 | 2-Bromo-5-fluorobenzoic acid | HCID 2778181 | — |
| 반응물 | 1'-Benzyl-6-chloro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 12213047 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 1'-Benzyl-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one | HCID 67377897 | — |
반응 단계
This reaction was performed as described for (i) above using 2-bromo-5-fluorobenzoic acid (2.19 g, 10.0 mmol), 1-benzylpiperidin-4-one (3.78 g, 20.0 mmol), n-butyl lithium (n-BuLi) (20 mL) and THF (20 mL) to give the sub-titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07449475B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-6270015648f2484cb820595c68701494 |
| 출처 메모 | uspto-grants-2008_11 |