1'-Benzyl-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-one → HCID 68959958, 화합물

HRID 270052노트

반응식

HRID 270052 반응식
C(N1CCC(CO)(CC2C=CC=CC=2F)CC1)C1C=CC=CC=1.[CH2:24]([N:31]1[CH2:36][CH2:35][C:34]2([C:40]3[CH:41]=[CH:42][C:43]([F:45])=[CH:44][C:39]=3[C:38](=O)[O:37]2)[CH2:33][CH2:32]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1>C1COCC1>[CH2:24]([N:31]1[CH2:36][CH2:35][C:34]2([C:40]3[CH:41]=[CH:42][C:43]([F:45])=[CH:44][C:39]=3[CH2:38][O:37]2)[CH2:33][CH2:32]1)[C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

참가 물질

4

반응물 2

HCID 673778971'-Benzyl-5-fluoro-3H-spiro[2-benzofuran-1,4'-piperidin]-3-oneHCID 68961767[1-Benzyl-4-(2-fluorobenzyl)piperidin-4-yl)methanol

생성물 1

HCID 68959958HCID 68959958, 화합물수율 77.5%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

This reaction was performed as described for (ii) above using 1′-benzyl-5-fluoro-3H-spiro[2-benzofuran-1,4′-piperidin]-3-one (200 mg, 0.642 mmol), borane THF complex 1M solution (1.34 mL, 1.34 mmol) and THF (3 mL) to give the sub-titled compound (148 mg).

출처 및 근거

ORD 기록
ord-5f269ca04b4045c2a6e89ce237e5ede7
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

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