Cyclopropylamine → N-Cyclopropyl-4-fluoro-2-hydroxybenzamide

HRID 270063노트

반응식

HRID 270063 반응식
[F:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=O)=[C:4]([OH:12])[CH:3]=1.[CH:13]1([NH2:16])[CH2:15][CH2:14]1>>[CH:13]1([NH:16][C:6](=[O:8])[C:5]2[CH:10]=[CH:11][C:2]([F:1])=[CH:3][C:4]=2[OH:12])[CH2:15][CH2:14]1

참가 물질

3

반응물 2

HCID 69828CyclopropylamineHCID 2775386Methyl 4-fluorosalicylate

생성물 1

HCID 68961144N-Cyclopropyl-4-fluoro-2-hydroxybenzamide

실험 절차

A suspension of methyl 4-fluoro-2-hydroxybenzoate (510 mg, 3.0 mmol) in cyclopropylamine (5 mL) was stirred at room temperature overnight when it became a clear solution. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum ether) to give the subtitled compound (493 mg).

후처리

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (0-30% ethyl acetate in petroleum ether)

출처 및 근거

ORD 기록
ord-bf55cd4353ca46b28da7938e0e45cb3d
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

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