Cyclopropylamine → HCID 28390698, 화합물

HRID 270065

반응식

HRID 270065 반응식
[OH:1][C:2]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:3]=1[C:4]([O:6]C)=O.[CH:14]1([NH2:17])[CH2:16][CH2:15]1>>[CH:14]1([NH:17][C:4](=[O:6])[C:3]2[CH:8]=[CH:9][C:10]([O:12][CH3:13])=[CH:11][C:2]=2[OH:1])[CH2:16][CH2:15]1

참가 물질

3

반응물 2

HCID 69828CyclopropylamineHCID 79523Methyl 4-methoxysalicylate

생성물 1

HCID 28390698HCID 28390698, 화합물

실험 절차

A suspension of methyl 2-hydroxy-4-methoxybenzoate (5.1 g, 28.0 mmol) in cyclopropyl amine 24 mL) was stirred at room temperature for 5 days. The volatiles were removed in vacuo and the residue was purified by silica gel flash chromatography (0-60% ethyl acetate in petroleum ether) to give the subtitled compound (1.8 g).

후처리

  1. customThe volatiles were removed in vacuo
  2. customthe residue was purified by silica gel flash chromatography (0-60% ethyl acetate in petroleum ether)

출처 및 근거

ORD 기록
ord-28b3b4d48a0f4850b7c740c5ce9c9a29
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

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