Trifluoroacetic acid water → 2-Acetylamino-5-benzoyloxyphenol

HRID 270069노트

반응식

HRID 270069 반응식
[C:1]([O:9][C:10]1[CH:19]=[CH:18][C:13]2[N:14]=[C:15]([CH3:17])[O:16][C:12]=2[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=[O:23].O>C([O-])(O)=O.[Na+]>[C:1]([O:9][C:10]1[CH:19]=[CH:18][C:13]([NH:14][C:15](=[O:23])[CH3:17])=[C:12]([OH:16])[CH:11]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 22392675Trifluoroacetic acid waterHCID 689598582-Methyl-6-benzoyloxybenzoxazole

생성물 1

HCID 689576202-Acetylamino-5-benzoyloxyphenol

시약·촉매·용매 1

HCID 516892Sodium Bicarbonate용매

실험 절차

To a solution of 2-methyl-1,3-benzoxazol-6-yl benzoate (5.05 g, 20 mmol) in THE (100 mL) a mixture trifluoroacetic acid/water (4 ml/10 mL) was added. The reaction mixture was stirred at room temperature for 16 h, then saurated aqueous NaHCO3 (150 mL) was added. The mixture was extracted with ethyl acetate (150 mL), dried over Na2SO4, filtered and concentrated in vacuo to give the subtitled compound.

후처리

  1. additionwas added
  2. extractionThe mixture was extracted with ethyl acetate (150 mL)
  3. dry with materialdried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-ba9e49b9af9e45a3a88a7ea6a9ac49b6
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

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