Cesium carbonate → N-{5-Chloro-2-[(2S)-oxiran-2-ylmethoxy]phenyl}acetamide

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	2-Acetylamino-4-chlorophenol	HCID 95258	—
반응물	Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester	HCID 146490	—
용매	Dimethylformamide	HCID 6228	—
생성물	N-{5-Chloro-2-[(2S)-oxiran-2-ylmethoxy]phenyl}acetamide	HCID 86601480	92.3%

반응 단계

A mixture of N-(5-chloro-2-hydroxyphenyl)acetamide (500 mg, 2.69 mmol), (2S)-oxiran-2-ylmethyl3-nitrobenzenesulfonate (697 mg, 2.69 mmol) and Cs2CO3 (1.04 g, 3.22 mmol) in DMF (10 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-50% ethyl acetate in petroleum ether) to give the subtitled compound (600 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07449475B2
출처 데이터셋	uspto-grants-2008_11
ORD ID	ord-ba1e445f47844faaa2ea1eba40902c38
출처 메모	uspto-grants-2008_11