Trifluoroacetic acid → 4-Acetamido-3-hydroxyphenyl acetate

HRID 270087노트

반응식

HRID 270087 반응식
[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]2[N:9]=[C:10]([CH3:12])[O:11][C:7]=2[CH:6]=1)(=[O:3])[CH3:2].FC(F)(F)C(O)=[O:18].C(=O)([O-])O.[Na+]>O1CCCC1>[C:1]([O:4][C:5]1[CH:14]=[CH:13][C:8]([NH:9][C:10](=[O:18])[CH3:12])=[C:7]([OH:11])[CH:6]=1)(=[O:3])[CH3:2]

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 156622632-Methylbenzo[d]oxazol-6-yl acetate

생성물 1

HCID 688181524-Acetamido-3-hydroxyphenyl acetate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-methyl-1,3-benzoxazol-6-yl acetate (8.1 g, 42.3 mmol) was dissolved in tetrahydrofuran (60 mL), and trifluoroacetic acid (4 mL, 53.2 mmol) was added. The light brown solution was stirred over night at room temperature. Sodium hydrogen carbonate (aq, sat) was added, and the solution was extracted twice with ethyl acetate. The combined organic layers were concentrated to the titled compound (8.0 g, 91%) as a beige solid.

후처리

  1. extractionthe solution was extracted twice with ethyl acetate
  2. concentrationThe combined organic layers were concentrated to the titled compound (8.0 g, 91%) as a beige solid

출처 및 근거

ORD 기록
ord-d8dbe9912e804bef8afffdec1554dd7c
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449475B2

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