Cesium carbonate → Methyl 4-methyl-2-[(2S)-oxiran-2-ylmethoxy]benzoate

참여 물질

역할	이름	HCID	투입량
반응물	Cesium carbonate	HCID 10796	—
반응물	Benzoic acid, 2-hydroxy-4-methyl-, methyl ester	HCID 78400	—
반응물	Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester	HCID 146490	—
용매	Dimethylformamide	HCID 6228	—
생성물	Methyl 4-methyl-2-[(2S)-oxiran-2-ylmethoxy]benzoate	HCID 71655300	—

반응 단계

A mixture of (2S)-oxiran-2-ylmethyl 3-nitrobenzenesulfonate (777.7 mg, 3.0 mmol), methyl 2-hydroxy-4-methylbenzoate ((498.5 mg, 3.0 mmol) and Cs2CO3 (1.17 g, 3.6 mmol) in DMF (10 mL) was stirred at room temperature overnight. The reaction mixture was partitioned between ethyl acetate and H2O. The organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel flash chromatography (0-20% ethyl acetate in petroleum spirit) to give the subtitled compound (500 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07449475B2
출처 데이터셋	uspto-grants-2008_11
ORD ID	ord-5da029fadcd84547a917c3e533b8f518
출처 메모	uspto-grants-2008_11