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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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5-chloro-6-[(triisopropylsilyl)oxy]-1,3-benzoxazol-2(3H)-one → N-{5-chloro-2-hydroxy-4-[(triisopropylsilyl)oxy]phenyl}cyclopentanecarboxamide

HRID 270131
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HRID 270131 반응식
Br[Mg][CH:3]1[CH2:7][CH2:6][CH2:5][CH2:4]1.[Cl:8][C:9]1[C:10]([O:19][Si:20]([CH:27]([CH3:29])[CH3:28])([CH:24]([CH3:26])[CH3:25])[CH:21]([CH3:23])[CH3:22])=[CH:11][C:12]2[O:16][C:15](=[O:17])[NH:14][C:13]=2[CH:18]=1>O1CCCC1>[Cl:8][C:9]1[C:10]([O:19][Si:20]([CH:24]([CH3:26])[CH3:25])([CH:27]([CH3:29])[CH3:28])[CH:21]([CH3:22])[CH3:23])=[CH:11][C:12]([OH:16])=[C:13]([NH:14][C:15]([CH:3]2[CH2:7][CH2:6][CH2:5][CH2:4]2)=[O:17])[CH:18]=1
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참가 물질

4

반응물 2

HCID 689628865-chloro-6-[(triisopropylsilyl)oxy]-1,3-benzoxazol-2(3H)-oneHCID 178419650HCID 178419650, 화합물

생성물 1

HCID 68962023N-{5-chloro-2-hydroxy-4-[(triisopropylsilyl)oxy]phenyl}cyclopentanecarboxamide수율 89%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

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온도
70 °C

실험 절차

Bromo(cyclopentyl)magnesium (0.58 mL, 1.16 mmol, 2 M in diethylether) was added under inert atmosphere to a solution of 5-chloro-6-[(triisopropylsilyl)oxy]-1,3-benzoxazol-2(3H)-one (66 mg, 0.19 mmol) in tetrahydrofuran (3 mL). After stirring over night at 70° C., the solution was evaporated and dissolved in ethylacetate. The organic layer was washed with water and 1M hydrochloric acid, dried and finally concentrated to give 68 mg (89%) of the subtitled compound as a brown solid.

후처리

  1. customthe solution was evaporated
  2. dissolutiondissolved in ethylacetate
  3. washThe organic layer was washed with water and 1M hydrochloric acid
  4. customdried
  5. concentrationfinally concentrated

출처 및 근거

ORD 기록
ord-79fd2906d9eb4002a0171c82a134f06d
출처 데이터셋
uspto-grants-2008_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07449475B2

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