Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thionyl Chloride → {[tert-Butyl(diphenyl)silyl]oxy}acetyl Chloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 2-((tert-Butyldiphenylsilyl)oxy)acetic acid | HCID 11141564 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | {[tert-Butyl(diphenyl)silyl]oxy}acetyl Chloride | HCID 19090360 | — |
반응 단계
In a 500ml round-bottom flask was mixed {[tert-butyl(diphenyl)silyl]oxy}acetic acid (17g, 54.0mmoles, 1eq), thionyl chloride (11.7g, 0.162moles, 3eq) and dry CH2Cl2(120ml, 0.45M). This mixture was refluxed for 5hours. After cooling to room temperature the volatiles were removed in vacuo. The resulting residue washed twice with toluene and the toluene was subsequently removed in vacuo to remove excess thionyl chloride. This resulted in 18g (100%) of titled compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07449468B2 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-4a51facb11084786b90bd8496d7c1722 |
| 출처 메모 | uspto-grants-2008_11 |