3-Methoxybenzenethiol → 2-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-ol

HRID 270389

반응식

[SH:1][C:2]1[CH:3]=[C:4]([O:8]C)[CH:5]=[CH:6][CH:7]=1.Br[CH:11]([CH3:24])[C:12]([C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][CH:15]=1)=O>>[CH3:24][C:11]1[S:1][C:2]2[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][C:7]=2[C:12]=1[C:14]1[CH:19]=[CH:18][C:17]([C:20]([F:21])([F:22])[F:23])=[CH:16][CH:15]=1

참가 물질

반응물 2

HCID 849893-Methoxybenzenethiol

HCID 104238192-Bromo-1-(4-(trifluoromethyl)phenyl)propan-1-one

생성물 1

HCID 179328792-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-ol

실험 절차

In analogy to examples 26.1-26.3, 3-Mercaptoanisole and 2-Bromo-1-(4-trifluoromethyl-phenyl)-propan-1-one were converted to yield 2-Methyl-3-(4-trifluoromethyl-phenyl)-benzo[b]thiophen-6-ol as colorless amorphous solid, MS: 308 (M).

출처 및 근거

ORD 기록: ord-1f4f2856f53b428eaa185762d9c4eb48
출처 데이터셋: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07449483B2

연결된 노트

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