Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfoxide → 4-(Propynyloxy)pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfoxide | HCID 679 | — |
| 반응물 | 3-Chloro-1-propyne | HCID 12221 | — |
| 반응물 | HCID 178418642 | HCID 178418642 | — |
| 촉매 | HCID 178418647 | HCID 178418647 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(Propynyloxy)pyridine | HCID 23343492 | 3.6% |
반응 단계
To a solution of 20.0 g (0.21 mole) 4-hydroxypyridine and 200 ml dimethyl sulfoxide was added 102 g (0.1 mole) silver carbonate. Propargyl chloride (22.5 g, 0.3 mole) was added to this suspension and the mixture heated at 50° for 6 hrs. After cooling to room temperature, the reaction mixture was diluted with water and extracted two times with ether. The combined ether extract was dried, filtered and concentrated as before to give 1.0 g of 4-(propynyloxy)pyridine. The product was 95% pure by vpc. The nmr and ir were compatible with the structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04220577 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-6a8c1777713940babd8f296f2d89bc27 |
| 출처 메모 | uspto-grants-1980_09 |