참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Azide | HCID 33557 | — |
| 반응물 | 4-Chlorobutyrophenone | HCID 253533 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | 4-Azidobutyrophenone | HCID 10877918 | 99% |
반응 단계
To a solution of 4-chloro-1-phenylbutan-1-one (26.4 mL, 164 mmol) in DMSO (200 mL) was added sodium azide (12.8 g, 197 mmol). The solution was warmed to 55° C. and stirred for 16 hours. The cooled mixture was then treated with water (600 mL) and extracted with ether (3×200 mL). The combined organics were washed with water (8×100 mL) and brine (100 mL) then dried over MgSO4 and concentrated to provide the product as an orange oil (30.7 g, 99%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07449486B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_11 |
|---|
| ORD ID | ord-253696dc1b55418da1f3a49de57430f7 |
|---|
| 출처 메모 | uspto-grants-2008_11 |
|---|
