Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Piperidinecarboxamide → 2-[2-(4-Carbamoylpiperidino)ethoxy]bibenzyl
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Piperidinecarboxamide | HCID 3772 | — |
| 반응물 | 2-(2-Bromoethoxy)bibenzyl | HCID 20545016 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-[2-(4-Carbamoylpiperidino)ethoxy]bibenzyl | HCID 12852582 | 82.3% |
반응 단계
A solution of 2 g of 2-(2-bromoethoxy)bibenzyl and 1.7 g of 4-piperidinecarboxamide in 20 ml of tetrahydrofuran and 10 ml of water was stirred at 70° C. for 10 hours. The reaction mixture was concentrated and to the residue was added 1 N NaOH aqueous solution. The resultant crystals were filtered, washed well with water and then recrystallized from ethanol to give 1.9 g (82% yield) of 2-[2-(4-carbamoylpiperidino)ethoxy]bibenzyl, m. p. 60°-63° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04220603 |
| 출처 데이터셋 | uspto-grants-1980_09 |
| ORD ID | ord-e92d68471f384dd693101c367d0b9ebe |
| 출처 메모 | uspto-grants-1980_09 |