Formaldehyde → 6,7-dihydro-4H-thieno[3,2-c]pyran

HRID 270651

반응식

HRID 270651 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][CH2:7][OH:8].[CH2:9]=O.[In+3]>C(#N)C>[S:1]1[C:2]2[CH2:6][CH2:7][O:8][CH2:9][C:3]=2[CH:4]=[CH:5]1

참가 물질

5

반응물 3

HCID 712FormaldehydeHCID 794002-ThiopheneethanolHCID 105148Indium cation

생성물 1

HCID 114691186,7-dihydro-4H-thieno[3,2-c]pyran수율 43%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

10.0 g of 2-thiopheneethanol, 2.8 g of paraformaldehyde, and 2.2 g of indium(III) triplate were added to 780 mL of acetonitrile, and the resulting mixture was refluxed for 12 hours. The reaction product solution was cooled to room temperature and concentrated by evaporation under reduced pressure. The residue was distilled under reduced pressure to obtain 4.7 g (yield of 43%) of the title compound, of which analysis data were the same as obtained in Example 14.

후처리

  1. temperaturethe resulting mixture was refluxed for 12 hours
  2. concentrationconcentrated by evaporation under reduced pressure
  3. distillationThe residue was distilled under reduced pressure

출처 및 근거

ORD 기록
ord-7e4a235f7bf04b8a8b320af81373770d
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449580B2

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