1,3-Dibromopropane → HCID 54351699, 화합물

HRID 27066노트

반응식

HRID 27066 반응식
C(=O)([O-])[O-].[K+].[K+].[CH3:7][C:8]1[CH:9]=[C:10]([CH:24]=[C:25]([CH3:28])[C:26]=1[OH:27])[C:11]([C:13]1[O:14][C:15]2[C:20]([C:21](=[O:23])[CH:22]=1)=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12].[Br:29][CH2:30][CH2:31][CH2:32]Br>CN(C)C=O>[Br:29][CH2:30][CH2:31][CH2:32][O:27][C:26]1[C:25]([CH3:28])=[CH:24][C:10]([C:11]([C:13]2[O:14][C:15]3[C:20]([C:21](=[O:23])[CH:22]=2)=[CH:19][CH:18]=[CH:17][CH:16]=3)=[O:12])=[CH:9][C:8]=1[CH3:7]

참가 물질

5

반응물 3

HCID 80011,3-DibromopropaneHCID 11430Potassium CarbonateHCID 64555162-(4-Hydroxy-3,5-dimethylbenzoyl)-4-benzopyrone

생성물 1

HCID 54351699HCID 54351699, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

27.6 g (0.2 mol) of potassium carbonate was added to a solution of 29.4 g (0.1 mol) of 2-(3,5-dimethyl 4-hydroxy benzoyl) chromone in 150 ml of dimethyl formamide, 101 g (0.5 mol) of 1,3-dibromo propane was added and the admixture left at ambient temperature for 15 hours with constant agitation. The potassium bromide precipitate was filtered, the dimethyl formamide was concentrated in vacuo and the residue dissolved in 300 ml of water. Extraction was effected with 200 ml of methylene chloride, and precipitation was then effected by adding 200 ml of ether. The product was 36 g of 2-[4-(3-bromo propoxy) 3,5-dimethyl benzoyl] chromone.

후처리

  1. additionwas added
  2. filtrationThe potassium bromide precipitate was filtered
  3. concentrationthe dimethyl formamide was concentrated in vacuo
  4. dissolutionthe residue dissolved in 300 ml of water
  5. extractionExtraction
  6. customwas effected with 200 ml of methylene chloride, and precipitation
  7. additionby adding 200 ml of ether

출처 및 근거

ORD 기록
ord-27d8c0d2087641c8b0183c2e60b2269a
출처 데이터셋
uspto-grants-1980_09
특허 번호
US04220645

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