참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Amino-2-(methylsulfanyl)pyrimidine-5-carbaldehyde | HCID 295769 | — |
| 반응물 | HCID 23185255 | HCID 23185255 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 59860298 | HCID 59860298 | 80% |
반응 단계
A mixture of 4-amino-2-methylsulfanyl-pyrimidine-5-carbaldehyde (2.0 g, 11.82 mmol), (3-amino-2,6-dichloro-phenyl)-acetonitrile (2.85 g, 14.18 mmol) and K2CO3 (4.9 g, 35.49 mmol) in DMF (20 mL) is heated to 110° C. for 30 hours. The solution is cooled to room temperature and the solid is removed by filter paper and concentrated to give crude product. Flash silica gel column purification, eluting with CH2Cl2 (100%) gradient to CH2Cl2/MeOH (2N NH3) (100/7%), gives the title intermediate as a solid (3.31 g, 80.0%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07449582B2 |
|---|
| 출처 데이터셋 | uspto-grants-2008_11 |
|---|
| ORD ID | ord-e4f4a8f10e67450f8d1fa16affa1cd13 |
|---|
| 출처 메모 | uspto-grants-2008_11 |
|---|
