Ethanol → HCID 86585161, 화합물
반응식
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[S:9])=[CH:6][N:5]=[C:4]([CH3:13])[N:3]=1.[CH3:14][NH2:15].C(O)C.O>ClCCl>[CH3:14][NH:15][C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[S:9])=[CH:6][N:5]=[C:4]([CH3:13])[N:3]=1참가 물질
6
실험 절차
To a solution of ethyl 4-chloro-2-methylthiopyrimidine-5-carboxylate (Aldrich, 20 g, 86 mmol) in 250 mL of dichloromethane at 0° C. was added slowly solution of methylamine in ethanol (33%, 35 mL 281 mmol). After stirring for 30 minutes, water (150 mL) was added and the phases were separated. The organic phase was dried (MgSO4) and filtered. The filtrate was evaporated under reduced pressure to give 19 g of the ethyl 4-methylamino-2-methylthiopyrimidine-5-carboxylate as a white solid.
후처리
- customthe phases were separated
- dry with materialThe organic phase was dried (MgSO4)
- filtrationfiltered
- customThe filtrate was evaporated under reduced pressure
출처 및 근거
- ORD 기록
- ord-1d43ee9774a045f89a3318a14c4be6fb
- 출처 데이터셋
- uspto-grants-2008_11
- 특허 번호
- US07449581B2
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