Chlorosuccinimide → 4-Chloro-5-isopropyl-3-trifluoromethylpyrazole

HRID 270794노트

반응식

HRID 270794 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:7]=[C:6]([CH:8]([CH3:10])[CH3:9])[NH:5][N:4]=1.C1C(=O)N([Cl:20])C(=O)C1>CC#N>[Cl:20][C:7]1[C:3]([C:2]([F:1])([F:11])[F:12])=[N:4][NH:5][C:6]=1[CH:8]([CH3:10])[CH3:9]

참가 물질

4

반응물 2

HCID 31398ChlorosuccinimideHCID 230062143-(trifluoroMethyl)-5-isopropyl-1H-pyrazole

생성물 1

HCID 210711494-Chloro-5-isopropyl-3-trifluoromethylpyrazole

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

Following protocol L, to the solution of 3-trifluoromethyl-5-isopropyl-pyrazole (0.22 g, 1.23 mmol) in CH3CN (10 mL) was added NCS (0.19 g, 1.43 mmol) in portions with vigorous stirring. The reaction mixture was then heated under reflux for 14 h, cooled and the reaction quenched with saturated NaHCO3, extracted with methylene chloride (2×30 mL) and the combined organic extracts was washed with brine, dried with Na2SO4 and evaporated to give the title compound as a white solid.

후처리

  1. temperatureThe reaction mixture was then heated
  2. temperatureunder reflux for 14 h
  3. temperaturecooled
  4. customthe reaction quenched with saturated NaHCO3
  5. extractionextracted with methylene chloride (2×30 mL)
  6. washthe combined organic extracts was washed with brine
  7. dry with materialdried with Na2SO4
  8. customevaporated

출처 및 근거

ORD 기록
ord-9287f4f1fbba4a4cbfe800707c6bd87f
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449576B1

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