Dichloromethane → 1-(Chloroacetyl)-4-(4-chlorophenyl)piperazine

HRID 270850

반응식

HRID 270850 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.CCN(CC)CC.[Cl:21][CH2:22][C:23](Cl)=[O:24].C(Cl)Cl>CCCCCC.C(OCC)(=O)C>[Cl:21][CH2:22][C:23]([N:11]1[CH2:12][CH2:13][N:8]([C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)[CH2:9][CH2:10]1)=[O:24]

참가 물질

6

반응물 4

HCID 6344DichloromethaneHCID 6577Chloroacetyl chlorideHCID 8471TriethylamineHCID 974781-(4-Chlorophenyl)piperazine

생성물 1

HCID 40539571-(Chloroacetyl)-4-(4-chlorophenyl)piperazine

시약·촉매·용매 1

HCID 21226206Ethyl acetate hexane용매

실험 절차

Protocol S was followed using 1-(4-chloro-phenyl) piperazine, Et3N, chloroacetyl chloride and methylene chloride. Column chromatography using a solvent mixture (hexane/ethyl acetate=1.5/1) afforded the title compound as a white solid.

출처 및 근거

ORD 기록
ord-43d6e56dc1bc410baeef2b93b516cdeb
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07449576B1

연결된 노트

불러오는 중…