Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 2-Chloro-1-[4-(4-bromo-3-methoxy-phenyl)-piperazin-1-yl]-ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Chloroacetyl chloride | HCID 6577 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1-(4-Bromo-3-methoxyphenyl)piperazine | HCID 21071016 | — |
| 용매 | Ethyl acetate hexane | HCID 21226206 | — |
| 생성물 | 2-Chloro-1-[4-(4-bromo-3-methoxy-phenyl)-piperazin-1-yl]-ethanone | HCID 21071125 | — |
반응 단계
Protocol S was followed using 1-(4-bromo-3-methoxyphenyl) piperazine, Et3N, chloroacetyl chloride and methylene chloride. Column chromatography using a solvent mixture (hexane/ethyl acetate=1.5/1) afforded the title compounds as a white solid
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07449576B1 |
| 출처 데이터셋 | uspto-grants-2008_11 |
| ORD ID | ord-5cbc3feeb2074068925eee7be2fe0c68 |
| 출처 메모 | uspto-grants-2008_11 |