Dimethylformamide → 2-(3-Amino-4-bromo-5-phenyl-pyrazol-1-yl)-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-Bromo-3-phenyl-1H-pyrazol-5-amine	HCID 594319	—
반응물	1-(Chloroacetyl)-4-(4-chlorophenyl)piperazine	HCID 4053957	—
용매	Ethyl acetate hexane	HCID 21226206	—
생성물	2-(3-Amino-4-bromo-5-phenyl-pyrazol-1-yl)-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone	HCID 21071044	—

반응 단계

Protocol T was followed using 4-Bromo-5-phenyl-1H-pyrazol-3-ylamine, K2CO3, 2-Chloro-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=1/4) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3); 7.7-7.8 (m, 2H), 7.24-7.3 (m, 3H), 6.8-6.92 (m, 2H), 6.74-6.78 (m, 2H), 4.9 (s, 2H), 4.2 (s, 2H), 3.6-3.7 (m, 4H), 2.86-3.04 (m, 4H). 13C NMR (400 MHz, CDCl3): 164, 146, 145, 128, 127, 118, 114.8, 60.2, 50.4, 50, 48.8, 46, 42, 22.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07449576B1
출처 데이터셋	uspto-grants-2008_11
ORD ID	ord-3b52df543c5541868cc6bfc0ee2fafeb
출처 메모	uspto-grants-2008_11