Dimethylformamide → 1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-(4-bromo-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone

참여 물질

역할	이름	HCID	투입량
반응물	Dimethylformamide	HCID 6228	—
반응물	Potassium Carbonate	HCID 11430	—
반응물	4-Bromo-3-methyl-5-(trifluoromethyl)pyrazole	HCID 2736430	—
반응물	1-(Chloroacetyl)-4-(4-chlorophenyl)piperazine	HCID 4053957	—
용매	Ethyl acetate hexane	HCID 21226206	—
생성물	1-[4-(4-Chloro-phenyl)-piperazin-1-yl]-2-(4-bromo-5-methyl-3-trifluoromethyl-pyrazol-1-yl)-ethanone	HCID 21070996	—

반응 단계

Protocol T was followed using 4-Bromo-5-methyl-3-trifluoromethyl-1H-pyrazole, K2CO3, 2-Chloro-1-[4-(4-chloro-phenyl)-piperazin-1-yl]-ethanone and DMF. Column chromatography using a solvent mixture (hexane/ethyl acetate=2/3) afforded the title compound as white solid. 1H NMR (400 MHz, CDCl3): 6.96-7.1 (m, 2H), 6.84-6.89 (m, 2H), 5.2 (s, 2H), 3.6.2-3.8 (m, 4H), 3.0-3.16 (m, 4H), 2.32 (s, 3H). 13C NMR (400 MHz, CDCl3): 162, 146.4, 142.2, 118.5, 116.2, 52, 50.4, 46.2, 42.2, 15.2.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US07449576B1
출처 데이터셋	uspto-grants-2008_11
ORD ID	ord-4642566c15634901b2aec0639f56fbc2
출처 메모	uspto-grants-2008_11